Advance Stage Disease---CYTOTOXIC THERAPY

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Advance Stage Disease---CYTOTOXIC THERAPY

As opposed to hormonal therapy which is primarily cytostatic (prevents cancer cells from growing), cytotoxic therapy is designed to kill the cancer cells. Radiation therapy and chemotherapy are examples of cytotoxic treatments.

Heretofore, the treatment of advanced stage, metastatic disease centered around palliation because there was no recognized therapy that provided any survival benefit to the patient. Prior to recent developments, the only approved treatment for advanced prostate cancer was the combination of mitoxantrone (Novantrone) and prednisone, which didn't improve survival but provided significant relief from the pain associated with advanced stage disease.

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