Who Is At Risk of Anal Cancer

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Who Is At Risk of Anal Cancer

We do not know the exact cause of most anal cancers. But we do know that certain risk factors are linked to anal cancer. A risk factor is something that increases a person's chance of getting a disease.

  • Age - Most people with anal cancer are over 50 years old.
  • Anal warts - Infection with the human papilloma virus (HPV) which causes condyloma (warts) may increase the chance of developing anal cancer.
  • Anal sex - Persons who participate in anal sex are at an increased risk.
  • Smoking - Harmful chemicals from smoking increase the risk of most cancers including anal cancer.
  • Immunosuppression - People with weakened immune systems, such as transplant patients who must take drugs to suppress their immune systems and patients with HIV (human immunodeficiency virus) infection, are at a somewhat higher risk.
  • Chronic local inflammation - People with long-standing anal fistulas or open wounds are at a slightly higher risk.
  • Pelvic radiation - People who have had pelvic radiation therapy for rectal, prostate, bladder or cervical cancer are at an increased risk.
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