Introduction for the General Physician

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Introduction for the General Physician

Aplastic anemia is a hematologic disorder characterized by a decrease in the cellular elements of the peripheral blood. This results from underproduction of peripheral blood elements due to bone marrow failure. Aplastic anemia develops before age 30-40 in patients who are predisposed due to a congenital chromosomal abnormality such as Fanconi's anemia or dyskeratosis congenita. Acquired aplastic anemia may be caused by toxic chemicals, radiation, or by idiosyncratic reactions to medications or infections. However, in over 50% of cases there is no identifiable cause and the condition is then referred to as idiopathic aplastic anemia.
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